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Nanomaterials, semiconductor materials, high-purity materials, custom processing
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Weekend: 10AM - 5PM
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Zhengzhou, Henan, China
dBET1
| Catalog No. | Ro-799711219 | CAS No. | 1799711-21-9 |
| Molecular Formula | C38H37ClN8O7S |
EINECS No. |
/ |
Purity :98%
Molecular weight: 785.27
Melting point:186 – 187°C
Density:1.55±0.1 g/cm3(Predicted)
Storage:Hygroscopic, -20°C Freezer, Under inert atmosphere
Solubility: Soluble in DMSO (a little), methanol (a little)
Apperance:Light yellow Solid
Acidity coefficient (pKa) :10.68±0.40 (Predicted)
Application: A CRBN-based BET degrader with an IC50 of 20 nM for BRD4 and high selectivity. Among the 7429 detected proteins, only the expressions of tumor proteins MYC, PIM1, and BRD2, BRD3, and BRD4 were significantly reduced after dBET1 treatment.
Other Names:
dBET1
DBET1
DBET-1
DBET1
CS-2706
6H-Thieno[3,2-f][1,2,4]triazolo[4,3-a][1,4]diazepine-6-acetamide,4-(4-chlorophenyl)-N-[4-[[2-[[2-(2,6-dioxo-3-piperidinyl)-2,3-dihydro-1,3-dioxo-1H-isoindol-4-yl]oxy]acetyl]amino]butyl]-2,3,9-trimethyl-,(6S)-
N-(4-{2-[(9S)-7-(4-chlorophenyl)-4,5,13-trimethyl-3-thia-1,8,11,12-tetraazatricyclo[8.3.0.0,2,6]trideca-2(6),4,7,10,12-pentaen-9-yl]acetamChemicalbookido}butyl)-2-{[2-(2,6-dioxopiperidin-3-yl)-1,3-dioxo-2,3-dihydro-1H-isoindol-4-yl]oxy}acetamide
2-((S)-4-(4-Chlorophenyl)-2,3,9-trimethyl-6H-thieno[3,2-f][1,2,4]triazolo[4,3-a][1,4]diazepin-6-yl)-N-(4-(2-((2-(2,6-dioxopiperidin-3-yl)-1,3-dioxoisoindolin-4-yl)oxy)acetamido)butyl)acetamide
dBET1,inhibit,PROTACs,EpigeneticReaderDomain,Inhibitor,dBET1,dBET-1
JQ1-ThalidomideconjugateRBAMATE
